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. 2021 Jan 29;40(7):1405–1412. doi: 10.1007/s10096-020-04145-7

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© The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 3 — Combination of heparin-binding protein (HBP) and interleukin (IL)-6 for the early prediction of 28-day mortality. (a) HBP admission concentrations among survivors and non-survivors. The p value of comparison by the Mann-Whitney U test is provided. Circles denote outliers, and asterisk denotes extremes. (b) IL-6 admission concentrations among survivors and non-survivors. The p value of comparison by the Mann-Whitney U test is provided. Circles denote outliers, and asterisk denotes extremes. (c) Survival curves of patients with increase of both HBP and IL-6 at admission and all other patients. The hazard ratio (HR) and the p value of significance are provided. (d) Risk of 28-day mortality among patients without any increase of admission HBP and IL-6, among patients with increase of only IL-6 or HBP, and among patients with increase of both HBP and IL-6. The p values of significance of the indicated comparisons are provided