Table 2.
Univariate and multivariate Cox regression analysis of parameters associated with 28-day mortality among patients with lower respiratory tract infection due to SARS-CoV-2
| Variable | 28-outcome | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| Survivors (n = 165) | Non-survivors (n = 13) | HR (95% CIs) | p value | HR (95% CIs) | p value | |
| CCI > 2 (n, %)# | 59 (35.8) | 9 (69.2) | 3.78 (1.16–12.30) | 0.001 | ||
| SOFA score > 3 (n, %)# | 39 (23.6) | 10 (76.9) | 9.32 (2.57–33.91) | 0.001 | ||
| PSI > 87 (n, %)# | 37 (22.4) | 9 (69.2) | 6.81 (2.09–22.12) | 0.001 | ||
| History of COPD (n, %) | 7 (4.2) | 3 (23.1) | 6.13 (1.68–22.30) | 0.006 | 18.68 (3.31–105.27) | 0.001 |
| Absolute lymphocyte count < 915/mm3 # (n, %) | 55 (33.3) | 10 (76.9) | 8.55 (1.79–40.90) | 0.007 | 7.43 (1.81–30.48) | 0.005 |
| IL-6 > 30 pg/ml# (n, %) | 33 (20.0) | 10 (76.9) | 11.31 (3.11–41.15) | 0.0002 | 8.81 (2.06–37.58) | 0.003 |
| HBP on day 1 > 35 ng/ml# (n, %) | 49 (29.7) | 11 (84.6) | 11.62 (2.59–52.71) | 0.001 | 28.74 (4.19–197.22) | 0.001 |
CCI Charlson Comorbidity Index, CI confidence intervals, COPD chronic obstructive pulmonary disease, HBP heparin-binding protein, HR hazard ratio, PSI pneumonia severity index, SOFA sequential organ failure assessment
#Cut-off point was determined based on the coordinate point with the maximum value of the Youden index