Skip to main content
. 2021 Jan 20;2021:6664386. doi: 10.1155/2021/6664386

Figure 4.

Figure 4

The difference of ICP expression, immune cells infiltration, and immunotherapy response between C1 and C2. (a) The expression heatmap of ICPs between C1 and C2 in metacohort. High expression, red; low expression, blue. (b) The abundance of 23 immune cell subsets infiltration was compared between the C1 and C2 in metacohort. ns, P > 0.05; ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001. (c) Correlations between immune checkpoints and HAGs in metacohort using Spearman analysis. Negative correlation was marked with blue, and positive correlation was marked with red. No asterisks represented no statistical significance; ∗P < 0.05; ∗∗P < 0.01. (d) Distribution of the immunotherapy response results predicted by TIDE algorithm between C1 and C2 in metacohort. Nonresponders, blue; responders, orange. (e) Submap analysis of the two subtypes and 47 previous melanoma patients with detailed immunotherapeutic information. NR represented nonresponders; R represented responders.