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. 2021 Jan 18;47(3):04856. doi: 10.3892/ijmm.2021.4856

Figure 1.

Figure 1

Mode of action of lncRNAs through different pathways for the development and progression of liver fibrosis. lncRNAs competitively bind to miRNAs and sequester them out of normal function. lncRNAs also affect epigenetic mechanisms, such as DNA and histone methylation by regulating the epigenetic enzymes, such as DNMTs. lncRNAs, long non-coding RNAs; miRNAs, microRNAs; DNMTs, DNA methyltransferases; HMTs, histone methyl transferases; α-SMA, α-smooth muscle actin.