Fig. 3.

Metabolites in which changes differed in PE and controls groups from first to third trimester. Raw p-value is shown, metabolites with significant p-values after FDR correction for multiple testing are shown in black. Cohen’s d values when compared to 1st trimester control samples and raw p-values from linear mixed model analysis are shown. The d-value shows the mean difference divided by standard deviation compared to mean metabolite level in the control group 1st trimester samples. Positive d-value means that the increased, and negative that they were decreased, when compared to the 1st trimester samples from the control group. The level of identifications for each metabolite can be found in the Supplementary Table 1. PE phosphatidylethanolamine, PC phosphatidylcholine, ACar acylcarnitine, LPE lysophosphatidylethanolamine, LPC lysophosphocholine, FA fatty acid, MAG monoacylglyceride