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. 2021 Jan 29;12:677. doi: 10.1038/s41467-021-21004-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Time course of simulated NMDA receptor activation, resulting from one or two release events at the indicated locations while varying the degree of depolarization of the postsynaptic membrane. The number averaged from 48 simulations is plotted. The vertical lines in the diagrams shown above the plot indicate when synchronous and asynchronous release occur. Synchronous release always occurs at time 0. Double release means two release events happen simultaneously. Synch synchronous, Asynch asynchronous. b The area under curve calculated from each data set in (a) and plotted as a bar graph. The locations of release are described in (a), and the degree of depolarization (depol) and the delay between synchronous and asynchronous release used in simulations are listed at the bottom. c Same as (a), but varying the interval between two release events. d Same as (b), but plotted from each data set in (c). e Same as in (a), but varying the order of the release. f Same as in (b), but plotted from each data set in (e) and plotted as a bar graph. A-N: synchronous release at AMPA receptors and asynchronous release at NMDA receptors. N-A: synchronous release at NMDA receptors and asynchronous release at AMPA receptors. N-N: both synchronous and asynchronous release at NMDA receptors. A-A: both synchronous and asynchronous release at AMPA receptors.