Table 2.

Development of enamel caries lesions with ICDAS code ≥ 1 or the progression of an existing enamel caries lesion by at least one ICDAS code in the PP-population and confidence intervals for the “risk difference”.

PP-population	Treatment/toothpaste
	HAP (test)		Fluoride (control)		Total
	n	%	n	%	n	%
ICDAS increase ≥ 1 per tooth
No	24	27.3%	23	25.8%	47	26.6%
Yes	64	72.7%	66	74.2%	130	73.4%
Total	88	100.0%	89	100.0%	177	100.0%

Primary endpoints	Population	Difference HAP-fluoride	Lower CI95% one-sided	Upper CI95% one-sided	Lower CI95% two-sided	Upper CI95% two-sided
Confidence Intervals for the “risk difference” HAP – fluoride
ICDAS increase ≥ 1 per tooth	PP	− 1.4%	− .12.4%	9.5%	− 14.4%	11.6%

CI95%, confidence interval; PP, per protocol; HAP, hydroxyapatite.