Table 4.

Development of at least one enamel caries lesions with ICDAS code ≥ 2 in the PP-population.

PP-population	Treatment/toothpaste
	HAP		Fluoride		Total
	n	%	n	%	N	%
Proportion of subjects with ICDAS increase ≥ 2 in at least one tooth up to visit 6 (after 48 weeks)
No	40	45.5%	37	41.6%	77	43.5%
yes	48	54.5%	52	58.4%	100	56.5%
Total	88	100.0%	89	100.0%	177	100.0%

Secondary endpoint	Population	Difference HAP-fluoride	Lower CI95% one-sided	Upper CI95% one-sided	Lower CI95% two-sided	Upper CI95% Two-sided
Confidence Intervals for the “risk difference” HAP-Fluoride
ICDAS increase ≥ 2 in at least one tooth up to visit 4 (after 24 weeks)	ITT	− 4.1%	− 16.4%	7.9%	− 18.3%	10.1%
ICDAS increase ≥ 2 in at least one tooth up to visit 6 (after 48 weeks)	ITT	− 3.9%	− 16.1%	8.4%	− 18.5%	10.7%