Table 2.

Sensitivity analysis of calculations for time to dialysis using lower and higher eGFR thresholds for dialysis [33]

Calculations	Placebo cohort	Canagliflozin cohort
eGFR threshold = 5 ml/min/1.73 m2
Time to dialysis = (5 − eGFR at week 3)/chronic slope	(5 – 55.45)/(–4.59) = 10.99 years	(5 – 52.28)/(–1.85) = 25.56 years
Delay in time to dialysis = canagliflozin time to dialysis − placebo time to dialysis	25.56 – 10.99 = 14.57 years
eGFR threshold = 15 ml/min/1.73 m2
Time to dialysis = (15 − eGFR at week 3)/chronic slope	(15 – 55.45)/(–4.59) = 8.81 years	(15 – 52.28)/(–1.85) = 20.15 years
Delay in time to dialysis = canagliflozin time to dialysis − placebo time to dialysis	20.15 – 8.81 = 11.34 years

eGFR estimated glomerular filtration rate