Table 7.
Outcomes following Prehab and surgery in the high risk patients compared with low risk patients.
| Parameter | Dyspnoea <3 and PS <2 vs. dyspnoea >3 and PS >2 |
DLCO 〈50% vs. DLCO 〉 80% |
|||||
|---|---|---|---|---|---|---|---|
| Low risk [Dyspnoea <3 and PS <2] (n-64) |
High risk [Dyspnoea >3 and PS >2] (n = 28) |
P | Low risk [DLCO > 80%] (n = 31) |
High risk [DLCO <50%] (n = 33) |
p | ||
| Outcome | Surgery | 55 (85.9) | 12 (42.8) | 0.0001 | 24 (77.4) | 18 (54.6) | 0.07 |
| Radiotherapy | 2 (3.1) | 6 (21.4) | 3 (9.7) | 7 (21.2) | |||
| Chemotherapy | 4 (6.25) | 2 (7.14) | 2 (6.5) | 5 (15.2) | |||
| Palliative care | 1 (1.56) | 5 (17.9) | 1 (3) | 3 (9.1) | |||
| Died before treatment | – | – | 1 (3) | – | |||
| Declined / no treatment | 2 (3.1) | 3 (10.7) | |||||
| Type of surgery | Lobectomy | 38 (70.4) | 5 (41.7) | 0.008 | 16 (66.7) | 6 (35.3) | ns |
| Segmentectomy | 6 (11.1) | 1 (8.3) | 1 (4.2) | 2 (11.8) | |||
| Pneumonectomy | 3 (5.6) | – | – | – | |||
| Wedge resection | 6 (11.1) | 5 (41.7) | 7 (29) | 9 (52.9) | |||
| Endobronchial excision | 1 (1.9) | – | – | – | |||
| Thoracotomy | – | 1 (8.3) | – | – | |||
| Surgical approach | Minimally invasive | 32 (59.3) | 9 (69.2) | ns | 16 (66.6) | 8 (47.1) | ns |
| Thoracotomy | 22 (40.7) | 4 (30.8) | 8 (33.4) | 9 (52.9) | |||
| Stay in HDU | Median (IQR) | 3 (2) | 3 (5) | ns | 3(2) | 4 (3.5) | 0.02 |
| Stay in Ward | Median (IQR) | 3 (3) | 3 (3) | ns | 3 (5) | 5 (5) | 0.03 |
| Length of hospital stay | Median (IQR) | 6 (5) | 7 (5.7) | ns | 6 (3.7) | 10 (8) | ns |
| Post- operative Complications | Major | 4 (7.3) | 2 (16.6) | ns | 3 (12.5) | 2 (11.8) | ns |
| Recidivism | 1 (1.8) | 1 (8.3) | ns | 1 (5.9) | 1 (4.2) | ns | |
| Post-operative Mortality | In hospital | 0 | 0 | ns | 0 | 0 | ns |
| 30 days | 0 | 0 | ns | 0 | 1 (5.9) | ns | |
| 90 days | 2 (3.6) | 1 (8.3) | ns | 0 | 2 (11.8) | ns | |
| 1 year | 7 (12.7) | 2 (16.7) | ns | 2 (8.3) | 5 (29.4) | ns | |
Values are numbers (percentage) unless otherwise stated. Minimally invasive approach included VATS and hybrid VATS. P values were calculated using Fishers exact test for categorical data and t-test for independent continuous variables by excluding unknown data.
CI= confidence interval; IQR= interquartile range; ns= not significant, n/a = not applicable; VATS= video assisted thoracoscopic surgery; 6MWT= six minute walk test.