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. 2021 Jan 29;12:687. doi: 10.1038/s41467-021-20907-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Cumulative distribution curves of epiallele shifts of the DNA methylome in AAH, AIS, MIA, and ADC specimens compared to normal lung, with 1st percentile of entropy as −21.46 for AAH, −28.88 for AIS, −30.75 for MIA, and −42.01 for ADC by quantile regression. b The abundance of eloci (loci with distinct epiallele shifts) among IPNs of different histologic stages. Each green dot represents the mean of normalized number of eloci in each IPN. The solid blue dots represent the mean numbers of eloci in the IPN of each histologic stage with 95% confidence interval as error bars. The differences among all stages were assessed using the Kruskal–Wallis H test. c The cumulative distribution curves of epipolymorphism for loci with significant epiallele shifts (ΔS < −60) in IPN specimens of AAH, AIS, MIA, and ADC, with 50th percentile of epipolymorphism as 0.295 for AAH, 0.362 for AIS, 0.359 for MIA, and 0.463 for ADC by quantile regression. X-axis denotes the epipolymorphism in IPN specimens at each loci. Y-axis denotes the cumulative fraction of epipolymorphism from all IPN specimens of each stage. Source data is provided as a source data file.