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. 2021 Jan 29;12:687. doi: 10.1038/s41467-021-20907-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Phylogenetic trees based on mutations (blue) and methylation values (green) in patient C5 (a), J7 (b), J8 (c), J9 (d), and J43 (e). The length of each branch indicates the similarity of mutation or methylation profiles between any pair of two spatially separated specimens from each patient. To avoid overfitting, only patients with IPNs having a minimum of four spatially separated specimens were included for this analysis. f Correlation of genetic distance (Hamming distance based on all mutations) and methylation distance (Euclidean distance based on methylation values of all CpG sites) between different spatially separated specimens from the same IPNs assessed by two-tailed Spearman’s correlation analysis (p = 2.62 × 10⁻³⁸). Each dot represents the normalized distance between each pair of specimens from the same IPNs. Source data is provided as a source data file.