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. 2021 Jan 29;12:687. doi: 10.1038/s41467-021-20907-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a LINE-1 methylation level in IPNs of different stages. Each green dot represents LINE-1 methylation level in each IPN and the solid blue dots represent the means of LINE-1 methylation level in IPNs of each histologic stage with 95% confidence intervals as error bars. The differences among all stages were assessed using the Kruskal–Wallis H test. Correlation between LINE-1 methylation levels and percent of genes with copy number changes (b), number of events with allelic imbalance (AI) (c), mutation burden (log 2 transformed) (d), and proportion of clonal mutations (e), assessed by two-tailed Spearman’s correlation analysis. Each dot represents each IPN specimen. Source data is provided as a source data file.