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. 2021 Jan 29;4:146. doi: 10.1038/s42003-020-01636-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a tSNE plot indicating transcriptomic similarities across cardiomyocytes obtained from all conditions. Different colors, symbols and numbers highlight the clusters as determined by k-medoids clustering of 1 − Pearson’s correlation coefficient. b Bar graph showing the proportion of cardiomyocytes originating from the different condition per cluster. c Heatmap showing expression of all genes significantly enriched in at least one cluster. Examples of genes enriched per cluster are depicted on the right side of the heatmap. d Bubble plot of top GO terms in gene ontology analysis on genes significantly enriched within the cluster. b–d Numbers highlighted in red depict a cluster that mainly contains 3 dp IR and 14 dp IR cardiomyocytes (cluster 5). e, f Cell trajectory analysis of cardiomyocytes, showing pseudotime on a color-coded scale (e) or highlighting the k-medoids cluster of each cardiomyocyte in the trajectory plot (f). The regions in the branches of the trajectory plot that contain mostly cells from k-medoids clusters 1,2,3 or cluster 4 or cluster 5 are highlighted by number.