Table 1.
Top ten transcription factors ranked by absolute change in node strength between inhibitor and control networks. P-values are calculated from permutations (see “Methods”).
| RV | Node strength diff. | P-value | Genes | Product |
|---|---|---|---|---|
| Rv0081 | −160.8 | 0.001 | transcriptional regulator, ArsR family | |
| Rv1033c | −123.6 | 0.001 | TrcR | DNA-binding response regulator TrcR |
| Rv0678 | −118.1 | 0.001 | Conserved protein | |
| Rv0324 | −108.2 | 0.001 | Transcriptional regulator, ArsR family | |
| Rv3597c | −106.9 | 0.001 | Lsr2 | Histone protein Lsr2 |
| Rv0967 | 97.2 | 0.021 | CsoR | Copper-sensitive operon repressor CsoR |
| Rv0465c | −89.0 | 0.005 | Transcriptional regulator, XRE family | |
| Rv1985c | −84.2 | 0.001 | HTH-type transcriptional regulator | |
| Rv3574 | −82.4 | 0.005 | KstR | Transcriptional regulator kstR (Rv3574), TetR family |
| Rv0023 | −77.5 | 0.002 | Transcriptional regulatory protein |