Table 2.

Peaks detected with conditional analysis of the EYS locus and associated non-synonymous variants.

	Peak 1	Peak 2	Peak 3
dbSNP rsID	rs76960013	rs59178556	rs79476654
Gene info	EYS:intron	EYS:intron	EYS:intron
Ref/Alt	A/G	C/A	T/C
ToMMo AF	0.0414	0.2161	0.0005
Odds ratio	3.95	1.83	16.46
P-value	1.18E−13	3.79E−10	2.45E−08
Linked variant	G843E	S2556C	S1653Kfs
dbSNP rsID	rs74419361	rs66462731	rs527236065
ToMMo AF	0.0171	0.214	0.0044
Odds ratio	3.75	1.79	NA†
P-value	1.06E−09	1.56E−09*	NA†
Corrleation (r2)	0.68	0.97	0.78
PolyPhen-2	Damaging	Possibly damaging	No data
SIFT	Damaging	Damaging/tolerated	Damaging
MutationTaster	Disease causing	Polymorphism	Disease causing
CADD score	23.8	22.9	No data

Information on the three independent peaks detected in this study and exonic variants in linkage disequilibrium are presented.

*P-value for S2556C was calculated after conditional analysis.

^†The odds ratio and P-value for S1653Kfs was not available (NA), because the variant was not included in the imputed genotypes of the GWAS analysis.