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. 2021 Jan 29;12:692. doi: 10.1038/s41467-020-20760-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Systemic signals such as HMGB1, HGFA, and the environmental pollutant TCDD (commonly known as dioxin) promote G_alert features in MuSCs through mTORC1 signaling. The Notch signaling pathway, critical for the maintenance of the quiescent state of MuSCs, was recently described to block proliferation and activation through KLF7-p21 and miRNA-708-Notch-migration axes, respectively. Finally, PTPN11/MAPK signals and cytosolic p57 are compatible with proliferation and activation of MuSCs. Color code: blue, receptor; beige, protein; purple, pathway.