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. 2021 Jan 29;11:2692. doi: 10.1038/s41598-021-82164-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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KAP1 inhibits Tat activity and cooperates with CTIP2 for this purpose (A–D) Microglial cells were transfected with LTR-Luc vector under the indicated conditions. After 48 h of transfection, the luciferase activities were measured after cell lysis and normalized under conditions where LTR-Luc vector were transfected alone. A t-test was performed on 3 independent experiments P (*P < 0.05, **P < 0.01, ***P < 0.001). (C,D) Over-expression and knockdown of the indicated proteins were validated by Western blot. Full-length blots are presented in Supplementary Figure 5.