Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 29;12:688. doi: 10.1038/s41467-020-20782-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a, b AFM-IR morphology maps of single oligomeric (light blue sphere) (a) and fibrillar species (dark blue rod) (b) of Aβ42. The morphology of the aggregates was reproducible and consistent on at least five independent and randomly chosen areas on the surface of each sample. c, d Nanoscale localised IR absorption spectra of oligomeric (c) and fibrillar species (d) of Aβ42. We represent two spectra: (i) the average + SE of the raw spectra and (ii) the average + SE of the preprocessed spectra by applying an adjacent averaging filter (5 pts) and a Savitzky–Golay filter (second order, 15 pts). At least five different raw spectra at each position (coloured crosses) were acquired. e, f The second derivatives of the spectra are calculated with a Savitzky–Golay filter (second order, 15 pts) to deconvolve the major secondary structural contributions of the oligomeric and fibrillar species.