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. 2021 Jan 29;12:683. doi: 10.1038/s41467-021-20982-2

Fig. 6. Conservation of t-NETs in human disease.

Fig. 6

A Representative confocal images of NETting neutrophils and CAFs in human pancreatic tumor biopsies (MPO, green; CitH3, red; podoplanin, blue; DAPI, white). B Representative confocal images of NETting neutrophils and CAFs in human melanoma primary tumor and metastasis samples (MPO, green; CitH3, red; podoplanin, blue; DAPI, white). C Median expression of app in human pancreatic adenocarcinoma and cutaneous melanoma compared to normal tissue from healthy donors and D Median expression of bace2 in human pancreatic adenocarcinoma and cutaneous melanoma compared to normal tissue from healthy donors (GTEx and TCGA datasets). E Correlation of app and bace2 with a lymphatic marker (lyve1) and CAF markers (pdpn, acta2, col1a2 and cd34). Kaplin–Meier curves showing overall survival of pancreatic adenocarcinoma and cutaneous melanoma patients correlated with high and low expression of (F) bace2 or (G) app. (A) Representative images of at least n = 3 tumors. Scale bars are 50 µm.