Fig. 4. Isothiocyanate-conjugated phalloidin labels both cell membrane and ciliary bundles for comparisons of the morphologies of the WT, untreated, and low- and high-dose-treated Kcne1^−/− mice at P30 (n = 4 in each group).

a The morphologies of marginal cells (MCs), ciliary bundles of cochlear, and vestibular hair cells (HCs) in WT mice as labeled. b The morphologies of MCs, ciliary bundles of cochlear, and vestibular HCs in untreated Kcne1^−/− mice. c The morphologies of MCs, ciliary bundles of cochlear, and vestibular HCs in low-dosage-treated Kcne1^−/− mice. The ciliary bundles of vestibular HCs in the utricle and crista ampullaris (CA) were significantly preserved. d The morphologies of MCs, ciliary bundles of cochlear, and vestibular HCs in high-dosage-treated Kcne1^−/− mice. The shape of the MCs and the ciliary bundles of the HCs in the cochlear and vestibular organs seemed to have recovered to normal. Red: phalloidin.