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. 2021 Jan 29;4:144. doi: 10.1038/s42003-021-01652-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The experimental model of peritoneal fibrosis (PF) was established by chlorhexidine gluconate (CG) induction for 21 days in wild-type (i.e., Fischer 344) and DPP4 deficient (DPP^D) rats. a Representative images of peritoneal tissue on day 21 were detected by immunofluorescent staining (200×) in SC-F344 (sham control, F344 wild type) and PF-F344 (peritoneal fibrosis, F344 wild type) rats for determining DPP4 (green color) and WT-1 positive signal (red color). DAPI labels cellular nuclei (blue color). b Histology of the peritoneum was observed by hematoxylin and eosin staining (H&E staining) in all the groups after CG-inducing PF. c Illustrating finding of Masson’s trichrome stain (200×) for identification of peritoneal fibrosis. d Quantitative result of peritoneal length by Masson’s trichrome stain in SC-F344, SC-DPP4^D, PF-F344, and PF-DPP4^D. e Quantitative result of peritoneal length by Masson’s trichrome stain in SC-F344, PF-F344, PF-F344 + Sita (sitagliptin), and PF-F344 + Exe4 (exendin-4). f, g Quantitative result of peritoneal area by Masson’s trichrome stain in each group. n = 6 for each group. Data represents the analysis and shows mean ± SD. Scale bars: 50 μm; HPF: high-power field. ** indicates p-value <0.01; *** represents p-value <0.001.