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. 2021 Jan 29;4:144. doi: 10.1038/s42003-021-01652-x

Fig. 5. DPP4 deficiency, sitagliptin, and exendin-4 reversed CG-inducing EMT process via SMAD3 pathway in rats.

Fig. 5

a Representative images (200×) of each group for identification of positively stained collagen-I (brown color) by immunohistology staining in peritoneal tissue after CG-inducing PF for day 21. Scale bars: 50 μm. b, c Quantitative result of positively stained collagen-I length in the peritoneum of each group. d Western blotting was performed to detect the protein levels of DPP4, collagen-I, TGF-β, and SMAD3 in the peritoneal tissues of F344 wild type (F344) or DPP4 deficient (DPP4D) rats. e Western blotting was performed to detect the protein levels of DPP4, collagen-I, TGF-β, and SMAD3 in the peritoneal tissues for evaluating therapeutic protection of sitagliptin and exendin-4. f, g Quantitative results of Fig. 5d and Fig. 5e were shown, respectively. n = 6 for each group. Data represents mean ± SD; * indicates p-value <0.05; ** represents p-value <0.01; and *** is p-value <0.001.