Table 4.
Characterization and General Properties of the Prepared DFZ Hydrogel Formulations
| Parameters | Plain Gel | Free-DFZ Gel | Optimized DFZ-UFNVs Gel |
|---|---|---|---|
| Appearance | Elegant, Transparent | Elegant, Translucent | Elegant, Translucent |
| Drug content (%) | 0 | 99.04 ± 1.36 | 98.15 ± 2.17 |
| pH | 7.12 ± 0.32 | 7.03 ± 0.27 | 7.32 ± 0.26 |
| Viscosity at 25°C | 8447.56 ± 3.94 | 9156.80 ± 2.51 | 1047.20 ± 3.03 |
| Mucoadhesion force (dyne/cm2) | 7416.52 ± 20.77 | 9910.60 ± 42.11 | 12,618.71 ± 53.31 |
| Farrow’s constant (N) | 2.35 ± 0.22 | 2.36 ± 0.21 | 2.32 ± 0.26 |
| Area of hysteresis loop (dyne/cm2.sec) | 679.29 ± 7.33 | 3624.26 ± 8.98 | 1698.70 ± 6.11 |
| Flow behavior | Pseudoplastic with thixotropy | ||
Note: Listed data are mean values ± SD (n=3).