. 2021 Jan 25;16:591–607. doi: 10.2147/IJN.S276330

Table 5.

Mean Pharmacokinetic Parameters for DFZ in Rabbit Plasma Following Administration of Oral DFZ Tablet, Transdermal Free DFZ Gel and Transdermal DFZ-UFNVs Gel

Pharmacokinetic Parameters	Mean ± SD
Pharmacokinetic Parameters	Oral Tablet	Transdermal Free DFZ Gel	Transdermal DFZ-UFNVs Gel
C_max (ng/mL)	96.58 ± 1.82	56.27 ± 1.12^a	113.77 ± 4.30^{a, b}
t_max (h)	1.00 ± 0.00	2.00 ± 0.00^a	2.00 ± 0.00^a
K_elim (h⁻¹)	0.2875 ± 0.0301	0.1883 ± 0.0241	0.0942 ± 0.0081^{a, b}
t_1/2 (h)	2.41 ± 0.29	3.68 ± 0.50^a	7.36 ± 0.61^{a, b}
AUC_0–24 (ng.h/mL)	345.51 ± 30.64	171.69 ± 14.62^a	547.32 ± 30.96^{a, b}
AUC_0–∞ (ng.h/mL)	470.04 ± 37.54	188.30 ± 16.38^a	645.21 ± 28.76^{a, b}
F_rel (%)	–	40.06	137.27^b

Notes: Values are means ± SD, with n = 3 for each group.Using one-way ANOVA followed by Tukey post-hoc test. ^ap < 0.05 versus oral DFZ tablets. ^bp < 0.05 versus transdermal free DFZ gel.