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. 2021 Jan 27;7(1):e06013. doi: 10.1016/j.heliyon.2021.e06013

Figure 1.

Figure 1

Comparison of WT and Mutated Structures for CADH1: WT: Gold; Mutant 1: Red (Ala634Val); Mutant 2: Cyan (Glu336Asp). CADH1 encodes a classical cadherin of the cadherin superfamily. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. It is observed that both mutations lead to noticeable structural rearrangements for both flexible ends of the protein. On the other hand, the local structure in the proximity of the mutations does not change in any noticeable way.