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. 2021 Jan 27;7(1):e06013. doi: 10.1016/j.heliyon.2021.e06013

Figure 14.

Figure 14

Comparison of WT and Mutated Structures for FH: WT: Gold; Mutant 1: Red (Asp179Asn). The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or the Krebs cycle, and catalyzes the formation of L-malate from fumarate. For this mutation, it is observed that both the overall and local structures for the WT and mutated proteins show almost perfect overlap.