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. 2021 Jan 27;7(1):e06013. doi: 10.1016/j.heliyon.2021.e06013

Figure 15.

Figure 15

Comparison of WT and Mutated Structures for MAP2K1: WT: Gold; Mutant 1: Red (Lys57Asn). The protein encoded by this gene is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. In this case, it is observed that there is a substantial overlap of the overall structure as well as the local one in the neighborhood of the mutation.