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Comparison of WT and Mutated Structures for PIK3CA: WT: Gold; Mutant 1: Red (Met1Val). This protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P, and PtdIns(4,5)P2. The overall structures of the WT and mutated proteins show substantial overlap, except for the terminal coil of the WT. Still, the local region of the mutation does not show any noticeable changes.
