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. 2021 Jan 27;7(1):e06013. doi: 10.1016/j.heliyon.2021.e06013

Figure 4.

Figure 4

Comparison of WT and Mutated Structures for VHL: WT: Gold; Mutant 1: Red (Ser65Leu); Mutant 2: Cyan (Tyr98His). Mutations in this protein are associated with Von Hippel-Lindau syndrome (VHL), which is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. The mutation considered here does not change the overall structure of the protein in a noticeable way or the local structure in the neighborhood of the Ser65Leu or Tyr98His mutations, which show almost perfect overlap.