Table 3.
Probability that the distributions of Table 2 features for WT and mutated structures are the same. The Mann-Whitney-Wilcoxon [28] test examines whether two samples are likely to derive from the same population taking as the null hypothesis that the distributions are equal. Therefore, a low p-value, here p = 0.05, after corrections is interpreted as that the feature may be used to distinguish between WT and mutated protein structures. The p values below 0.05 are presented in bold.
Predicted Structural Feature | P-value After Correction (BH) |
---|---|
Root mean square deviation of atomic position | 5.815e-01 |
Confidence score | 2.032e-02 |
Template modeling Score | 5.6e-01 |
Solvent accessible surface area | 1.6e-05 |
Total Gibbs free energy | 2.03e-02 |
Pairwise distance-dependent energy | 2.56e-02 |
Sidechain orientation-dependent energy | 2.56e-02 |
Distance-related energy | 2.56e-02 |
Angle-related energy | 4.78e-02 |