Table 2. Characteristics of Seropositive Mothers and Their Newbornsa.
| Characteristic | No. (%) | P value | |
|---|---|---|---|
| Seropositive (n = 72) | Seronegative (n = 11) | ||
| Maternal | |||
| Age, median (IQR), y | 29 (25-33) | 28 (22-32) | .33 |
| Race/ethnicity | |||
| Black/non-Hispanic | 32 (44) | 4 (36) | .17 |
| White/non-Hispanic | 10 (14) | 2 (18) | |
| Asian | 1 (1) | 1 (9) | |
| Hispanic | 28 (39) | 3 (27) | |
| Otherb | 1 (1) | 1 (9) | |
| Gravidity | |||
| 1 | 13 (18) | 1 (9) | .67 |
| 2 | 17 (24) | 4 (36) | |
| ≥3 | 42 (58) | 6 (55) | |
| Prepregnancy BMI | |||
| <18.0 | 3 (4) | 0 | .17 |
| 18.5-<25.0 | 18 (25) | 6 (55) | |
| 25.0-<30.0 | 26 (36) | 4 (36) | |
| ≥30.0 | 25 (35) | 1 (9) | |
| Diabetes | 6 (8) | 0 | >.99 |
| Hypertension | 15 (21) | 2 (18) | >.99 |
| Multiple gestation | 0 | 2 (18) | .02 |
| Cesarean delivery | 17 (24) | 2 (18) | >.99 |
| GA at delivery, median (IQR), wk:d | 39:3 (38:0-40:0) | 39:1 (37:3-39:5) | .39 |
| Preterm delivery at GA <37 wk | 7 (10) | 2 (18) | .34 |
| Infant sex (male) | 31 (43) | 2 (18) | .19 |
| Birth weight, median (IQR), g | 3315 (2940-3625) | 2990 (2500-3200) | .07 |
| Apgar score at 5 min <5c | 1 (1) | 0 | >.99 |
| Time between maternal sera sampling and delivery, median (IQR), h | 9 (4-20) | 14 (6-17) | .92 |
| NP-PCR tested during pregnancy | 71 (99) | 11 (100) | >.99 |
| NP-PCR positive | 38 (54) | 6 (55) | >.99 |
| Time between positive NP-PCR test result and delivery, median (IQR), d | 34 (1-72) | 6 (0-12) | .04 |
| Maternal IgG seropositive | 72 (100) | 6 (55) | <.001 |
| IgG concentration, geometric mean (95% CI)d | 5.22 (3.97-6.87) | 1.27 (0.57-2.82) | .005 |
| Maternal IgM seropositive | 41 (57) | 7 (64) | .75 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); GA, gestational age; IQR, interquartile range; NP-PCR, nasopharyngeal polymerase chain reaction.
a
N = 83 paired maternal and neonatal cord sera.
b
Other included patient option to not define race/ethnicity (1) and to choose more than 1 race/ethnicity category (1).
c
Apgar score at 5 minutes was missing for 2 seropositive infants.
d
Only values >0.48 arbitrary units/mL included in the calculation of geometric mean.