Table 7. Prediction of molecular interaction of Cyclin D1 with other proteins using STRING.
Predicted functional partners | Confidence scores* | Prediction for specific action |
---|---|---|
CDK4 Cyclin-dependent kinase 4 |
0.995 | Binding, activation, catalysis, reaction, inhibition, expression with inhibition, and post-translational modification |
CDK6 Cyclin-dependent kinase 6 |
0.880 | Binding, post-translational modification, catalysis, reaction, and inhibition |
CDKN1A Cyclin-dependent kinase inhibitor 1 |
0.993 | Binding, activation, catalysis, reaction, and inhibition |
IFNAR1 Interferon alpha/beta receptor 1 |
0.993 | No direct predicted action |
MCM10 Protein MCM10 homolog |
0.872 | No direct predicted action |
CDK2 Cyclin-dependent kinase 2 |
0.853 | Binding, activation, catalysis, reaction, and inhibition |
CDKN1B Cyclin-dependent kinase inhibitor 1B |
0.689 | Binding, inhibition catalysis, and reaction |
CDKN1C Cyclin-dependent kinase inhibitor 1C |
0.814 | Binding, reaction, and inhibition |
CDK1 Cyclin-dependent kinase 1 |
0.781 | Binding, activation, catalysis, reaction, and inhibition |
ORC4 Origin recognition complex subunit 4 |
0.722 | No direct predicted action |
Confidence score = how likely STRING judges an interaction to be true. 0–1, where 1 is highest confidence and ≤ 0.5 represents a false positive interaction.