Skip to main content
. 2021 Jan 29;135(2):387–407. doi: 10.1042/CS20200480

Figure 2. Schematic depicting the opposing effects of ACE/AngII/AT1R axis and ACE2/Ang-(1-7)/Mas1 axis in the vasculature.

Figure 2

Increased signalling through the ACE/AngII/AT1R axis promotes vascular injury while signalling through the ACE2/Ang-(1-7)/Mas1 axis leads to vasoprotection from the injury caused by ACE/AngII/AT1R axis stimulation. ACE, angiotensin-converting enzyme; ACE2, angiotensin converting enzyme two; Ang II, angiotensin two; Ang-(1-7), angiotensin 1 to 7; AT1R, angiotensin two type one receptor; Mas1, mas1 receptor.