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. 2020 Oct 21;320(1):C132–C141. doi: 10.1152/ajpcell.00166.2020

Figure 1.

Figure 1.

Spag6 deficiency affects auditory function. A and B: auditory brainstem response (ABR) thresholds (dB SPL) determined by click and pure tones in 1-mo-old wild-type (WT) and Spag6-deficient mice of either gender (Spag6+/+; n = 9; Spag6−/−; n = 7; means ± SE). Spag6−/− mice showed severe hearing loss, the average ABR threshold response to click was significantly higher than that in the wild-type mice (A). Analysis of hearing function in response to pure tones (4, 8, 16, and 32 kHz) also confirmed elevated thresholds at different frequencies in Spag6-deficient mice (B). The average cochlear microphonics (CM) threshold response to click of Spag6−/− mice was significantly higher than that in the wild-type mice (C) (Spag6+/+; n = 4; Spag6−/−; n = 3; means ± SE). *P < 0.05, Student’s t-test. SPL, sound pressure level.