Fig. 7.

CircZFR promotes the growth of cervical cancer cells in vivo. a. Nude female mice were subcutaneously injected with 2 × 10⁷ stably overexpressed circZFR and the corresponding control HeLa cells (n = 10 for each group), and the tumors were extracted after 21 days. b. The volume of tumors in figure a was measured every 3 days. c. The weight of tumors in figure a was measured. d. Nude female mice were subcutaneously injected with 2 × 10⁷ stably knockdown circZFR and the corresponding control HeLa cells (n = 10 for each group), and the tumors were extracted after 21 days. e. The volume of tumors in figure d was measured every 3 days. f. The weight of tumors in figure d was measured. g. Model of circZFR-mediated p-Rb phosphorylation promoting the G1/S transition and cell proliferation in cervical cancer. ****P< 0.0001