Table 2.
Characteristics of patients with Behçet’s syndrome after clustering on clinical manifestations
| Characteristics | C1 (n = 307) | C2 (n = 124) | C3 (n = 156) | C4 (n = 142) | C5 (n = 131) |
|---|---|---|---|---|---|
| Demographics | |||||
| Age (IQR), years | 36 (27–47) | 39 (29–48) | 37 (28–48) | 33 (27–42) | 37 (29–44) |
| Age at onset (IQR), years | 28 (20–38) | 28 (19–37) | 28 (19–38) | 25 (20–32) | 27 (21–35) |
| Disease duration (IQR), years | 6 (3–10) | 9 (4–10) | 6 (3–10) | 7 (4–10) | 6 (3–10) |
| Krause score | 3 (2–3) | 4 (3.3–5) | 4 (4–5) | 6 (5–6) | 6 (5–7) |
| Sex ratio (M/F) | 0.64:1 | 0.97:1 | 1.08:1 | 2.94:1 | 2.54:1 |
| Classification criteria | |||||
| JPN (%) | 52.4 | 41.9 | 22.4 | 83.8 | 43.5 |
| CHN (%) | 100 | 99.2 | 94.2 | 99.3 | 91.6 |
| ICBD (%) | 100 | 79.0 | 62.8 | 99.3 | 87.8 |
| ISG (%) | 52.8 | 45.2 | 23.1 | 81.7 | 43.5 |
| Clinical manifestation | |||||
| Oral ulceration (%) | 100 | 100 | 98.0 | 99.2 | 100 |
| Genital ulceration (%) | 100 | 75.8 | 61.5 | 58.5 | 63.4 |
| Erythema nodosum (%) | 40.7 | 44.4 | 19.2 | 48.6 | 49.6 |
| Folliculitis (%) | 20.8 | 28.2 | 25.6 | 28.2 | 22.1 |
| Arthritis/arthralgia (%) | 0 | 100 | 1.3 | 16.9 | 23.7 |
| Major organ involvement | |||||
| Uveitis (%) | 0 | 0 | 0 | 100 | 9.9 |
| Intestinal involvement (%) | 0 | 14.5 | 92.3 | 5.6 | 6.1 |
| Esophageal lesions (%) | 0 | 1.6 | 20.5 | 0.7 | 0.8 |
| Vascular involvement (%) | 0 | 0 | 0 | 0 | 44.3 |
| Cardiac lesion (%) | 0 | 0 | 0 | 0 | 33.6 |
| Myelodysplastic syndrome (%) | 0.3 | 1.6 | 1.9 | 0 | 0 |
| Central nervous system involvement (%) | 0 | 0.8 | 1.9 | 0.7 | 19.8 |
Values presented as n (%) unless otherwise stated. JPN Diagnostic criteria of the Behçet’s disease research committee of Japan (1987 revision), CHN the Chinese version of Behçet’s disease criteria created by Cheng and Zhang, ICBD International Criteria for Behçet’s disease, ISG International Study Group for Behçet’s disease