Table 1.
Description of selected quality control terms as they relate to the Kidney Precision Medicine Project
| Term | Description |
|---|---|
| Complementarity | Different types of information gained from different technologies to describe the tissue composition and the relationships among its constituents |
| Follow the tissue | The different steps that the tissue undergoes during its interrogation from collection to preservation, processing, storage, shipping, assay, analysis, and data dissemination |
| Harmonization | Efforts to combine data from different sources including file formats, nomenclature into a cohesive and comparable format for analysis, and interpretation |
| Metadata | Information or data associated with each aspect of the process of tissue collection, its interrogation, and analysis |
| Metadata modeling | Development of rules and framework to define how to build relationships between concepts of a defined domain |
| Multimodal | Different ways (technologies) to interrogate the tissue in KPMP |
| Ontologize | The act of converting into ontological terms or entities |
| Ontology | A human- and computer-interpretable set of terms and relations that represent entities in a specific domain and how they relate to each other |
| Orthogonal validation | Using different technologies or assays to verify a given observation |
| Pipeline | The process through which each aspect of tissue interrogation is systematically done (example, tissue preservation pipeline, tissue processing pipeline) |
| Standardization | The process by which critical elements of quality control parameters in “follow the tissue” are established and implemented to minimize sources of errors and technical variations and ensure consistent results are produced for a particular technology |
| Technology drift | Changes in a technology or its components over time that can impact the reproducibility of results |
| Tissue interrogation | The act of using different techniques and tools to identify, analyze and determine the 2-D/3-D relationships between cells, their extracellular environment, and their molecular components including gene, protein, and metabolite expressions |