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H4K20 methylation biology. Lysine 20 of histone H4 (H4K20) can be un-, mono-, di-, or trimethylated (red circle) each of which has distinct biological functions (gray boxes). Methyltransferase enzymes catalyze the conversion of H4K20 into these methylated states. Demethylase enzymes remove methyl groups from H4K20. Dashed lines represent recently reported enzymes that require more evidence to determine reproducibility.
