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. 2020 Nov 16;320(1):F47–F54. doi: 10.1152/ajprenal.00398.2020

Fig. 3.

Fig. 3.

A: placental mitochondrial reactive oxygen species (ROS) significantly increased in reduced uterine perfusion pressure (RUPP) (n = 5) vs. normal pregnant (NP) (n = 5) (207.9 ± 13.98 vs. 100 ± 13.41% gated, P < 0.05) and RUPP vs. RUPP + Orencia (n = 8) (207.9 ± 13.98 vs. 60.33 ± 1.74% gated, P < 0.05). NP + RUPP CD4+ T cells (n = 3) (196.9 ± 14.47% gated, P < 0.05) underwent an elevation in mitochondrial placental ROS compared with NP controls (100 ± 13.41% gated). There was a significant decrease observed in placental mtROS in RUPP rats administered Orencia vs. NP + RUPP CD4+ T-cell rats (60.33 ± 1.74 vs. 196.9 ± 14.47% gated, P < 0.05). The results represent means ± SE. *P < 0.05. B: renal mitochondrial ROS significantly increased in RUPP (n = 4) vs. NP (n = 5) (792.2 ± 163.9 vs. 100 ± 22.95% gated, P < 0.05), NP + RUPP CD4+ T cells (n = 5) vs. NP (200.2 ± 29.3 vs. 100 ± 22.95% gated, P < 0.05), and RUPP vs. RUPP + Orencia (n = 9) (792.2 ± 163.9 vs. 265.9 ± 32.2% gated, P < 0.05). There was a decreased observed in renal mitochondrial ROS in RUPP rats administered Orencia vs. NP + RUPP CD4+ T-cell rats (265.9 ± 32.2 vs. 200.2 ± 29.3% gated). The results represent means ± SE. *P < 0.05.