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. 2020 Oct 7;320(1):L99–L125. doi: 10.1152/ajplung.00381.2020

Figure 5.

Figure 5.

Transcriptional responses in the parenchyma. A: two-dimensional principal component (PC) analysis plot using PC1 and PC2 on all the detected genes (after normalization) in the parenchyma from air- and ozone-exposed mice. B: two-dimensional principal component (PC) analysis plot using PC1 and PC3 on all of the detected genes (after normalization) in the parenchyma from air- and ozone-exposed mice. C–F: volcano plots depicting differentially expressed genes (DEGs, upregulated and downregulated) in four different comparisons that were identified using cutoff criteria (Log2 Fold change > 2, adjusted P values < 0.05). C: air-exposed females vs. air-exposed males (DEGs = 7). D: ozone-exposed males vs. air-exposed males (DEGs = 488). E: ozone-exposed females vs. air-exposed females (DEGs = 446). F: ozone-exposed females vs. ozone-exposed males (DEGs = 6). (n = 4 per sex per treatment). G: Venn diagram depicting common and unique DEGs (upregulated and downregulated) in ozone-exposed males vs. air-exposed males and ozone-exposed females vs. air-exposed females. H: volcano plots depicting differentially expressed genes (DEGs; upregulated and downregulated) in the parenchyma from ozone-exposed mice vs. air-exposed mice.