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. 2020 Oct 7;320(1):L99–L125. doi: 10.1152/ajplung.00381.2020

Figure 7.

Figure 7.

Transcriptional responses in purified macrophages. A: two-dimensional principal component (PC) analysis plot using PC1 and PC2 on all the detected genes (after normalization) in macrophages from air- and ozone-exposed mice. B: two-dimensional PC analysis plot using PC2 and PC3 on all the detected genes (after normalization) in macrophages from air- and ozone-exposed mice. C–F: volcano plots depicting differentially expressed genes (DEGs, upregulated and downregulated) in four different comparisons that were identified using cutoff criteria (Log2 fold change > 2, adjusted P values < 0.05). C: air-exposed females vs. air-exposed males (DEGs = 922). D: ozone-exposed males vs. air-exposed males (DEGs = 666). E: ozone-exposed females vs. air-exposed females (DEGs = 680). F: ozone-exposed females vs. ozone-exposed males (DEGs = 5). (n = 4 per sex per treatment). G: Venn diagram depicting common and unique DEGs (upregulated and downregulated) in ozone-exposed males vs. air-exposed males and ozone-exposed females vs. air-exposed females. H: volcano plots depicting DEGs (upregulated and downregulated) in macrophages from ozone-exposed mice vs. air-exposed mice.