Table 1.

Top 20 upregulated genes and top 20 downregulated genes in airways in designated comparisons

Air			Ozone			Males			Females
Females vs. Males			Females vs. Males			Ozone vs. Air			Ozone vs. Air
Gene	FC	Adjusted P Value	Gene	FC	Adjusted P Value	Gene	FC	Adjusted P Value	Gene	FC	Adjusted P-Value
Top 20 upregulated genes
Xist	311.48	0	Xist	65.38	0	Psca	18.22	1.09E−58	Psca	21.55	1.36E−53
Oxtr	2.04	7.66E−06	Rpl23a	1.88	4.85E−05	Foxn4	13.04	3.56E−45	Anxa10	17.75	3.83E−47
Dusp5	1.84	9.85E−05	Rtp4	1.78	0.00028167	Krt13	10.09	7.58E−55	Krt13	16.52	1.06E−43
Nts	1.81	7.69E−05	Phf11d	1.67	0.005181	Cdc20b	9.79	1.85E−32	Serpinb2	13.87	1.44E−44
Foxn4	1.80	0.00042413	Ifit1	1.67	0.0074655	Mcidas	9.65	1.18E−30	Upk3bl	12.57	7.39E−103
Bpifb5	1.77	0.00012054	Usp18	1.65	0.005181	Ccno	8.86	7.13E−31	Cwh43	11.32	8.29E−41
Pnpla3	1.68	3.96E−05	I830012O16Rik	1.62	0.0091607	Ccna1	8.19	2.45E−34	Calcb	8.50	7.03E−29
Lctl	1.60	0.0040662	Oas2	1.61	0.020394	Krt4	7.40	1.38E−72	Vsig1	7.88	4.22E−23
Adamts9	1.60	0.0043958	Isg15	1.61	0.019942	Anxa10	7.39	2.75E−23	Krt4	7.17	6.86E−41
Clca3	1.60	0.013739	Ifi44	1.60	0.023295	Sprr2a3	7.37	2.55E−21	Ly6g6c	6.96	1.08E−24
Col6a5	1.59	4.72E−05	Igkv8–30	1.59	0.017466	Ly6g6c	7.23	9.61E−56	Serpinb10	6.75	8.55E−34
Eci3	1.59	0.01583	Oas1g	1.59	0.023295	Stil	7.01	2.23E−28	Sptssb	6.47	4.63E−21
Kdm6a	1.56	1.72E−08	Rsad2	1.59	0.031367	Pbk	6.91	1.33E−57	Syt8	6.42	8.34E−29
Mc2r	1.56	0.024325	Apol9a	1.58	0.023295	Upk3bl	6.78	1.65E−64	Cdc20b	6.27	8.17E−17
Aldh1a2	1.55	1.23E−07	Ifit3	1.58	0.019704	Cwh43	6.69	1.01E−40	Pbk	6.06	1.23E−29
Kdm5c	1.54	4.43E−08	Kdm6a	1.57	0.00023265	Ccdc18	6.34	1.34E−39	Muc13	5.95	2.53E−15
Tpsab1	1.54	0.023899	Atpif1	1.57	0.0024485	Ccdc67	6.27	6.49E−23	Atg9b	5.45	3.92E−23
C1qtnf3	1.53	0.0087593	Dnm3os	1.55	0.0024485	Cdk1	6.20	1.12E−38	Dsg3	5.40	5.31E−14
Wt1	1.53	0.014613	Rps29	1.54	0.0080438	Serpinb2	6.07	1.98E−25	Cdk1	5.39	2.49E−25
Thbs1	1.51	0.045931	Mx2	1.53	0.045486	Spag5	5.92	1.05E−42	Esco2	5.33	3.99E−19
Top 20 downregulated genes
Ddx3y	−96.90	0	Ddx3y	−46.14	0	Cdh26	−10.37	4.22E−98	Aoc1	−15.11	6.74E−81
Eif2s3y	−75.29	0	Eif2s3y	−26.18	3.07E−199	Aoc1	−8.66	1.75E−41	Cdh26	−10.72	1.02E−47
Kdm5d	−48.31	1.26E−262	Uty	−21.15	8.88E−180	Erich5	−6.81	1.52E−22	Slc35g3	−9.50	8.15E−30
Uty	−34.03	1.28E−205	Kdm5d	−19.49	3.72E−161	Slc35g3	−6.36	9.07E−22	Unc79	−8.65	2.46E−52
Slc26a7	−17.13	1.61E−129	RP24–540G19.3	−3.96	2.69E−30	Unc79	−6.16	8.44E−31	Erich5	−6.72	3.75E−18
Scg2	−10.05	1.69E−69	Sult1e1	−1.70	0.0015006	Gm281	−4.84	2.70E−36	Gm281	−5.21	3.27E−30
Calca	−8.88	8.80E−58	Fbxo21	−1.32	0.005181	4833428L15Rik	−4.63	7.20E−14	Tbata	−5.16	5.42E−24
Iyd	−7.85	2.81E−56	Snd1	−1.27	0.041251	4930562C15Rik	−4.58	7.35E−56	Gm12695	−4.95	3.17E−34
Ano5	−7.56	1.71E−54				Ldlrad1	−3.96	2.63E−21	Gtsf1l	−4.93	4.11E−16
Prlr	−7.23	6.26E−67				Gm12695	−3.90	3.24E−15	BC007180	−4.83	1.59E−34
Slc26a10	−7.06	4.99E−60				BC007180	−3.82	4.87E−16	Wdr95	−4.72	1.92E−24
Folr1	−6.64	1.74E−43				Fam166b	−3.79	8.80E−17	2010001K21Rik	−4.61	3.96E−14
RP24–540G19.3	−5.98	1.01E−38				2010109I03Rik	−3.71	5.29E−12	Ankrd65	−4.60	1.14E−35
Kcnh3	−5.70	6.52E−46				Erich3	−3.70	1.56E−15	Erich3	−4.57	7.87E−20
Prom2	−5.15	8.38E−38				Cdhr3	−3.65	4.48E−27	4930562C15Rik	−4.47	1.38E−54
Gjb1	−5.09	1.07E−40				Stmnd1	−3.64	8.07E−20	Stmnd1	−4.36	1.47E−34
Scg5	−4.91	2.52E−34				Gm20661	−3.64	8.99E−15	Ccdc33	−4.18	2.51E−35
Fxyd4	−4.30	6.27E−29				Pklr	−3.63	5.56E−09	Cdhr3	−4.17	2.35E−27
Wisp1	−4.28	9.53E−73				Gtsf1l	−3.60	1.00E−13	Ldlrad1	−4.10	3.55E−34
Gm12446	−4.13	1.07E−23				Wdr95	−3.46	2.33E−14	Ky	−4.10	2.75E−27