Table 3.
Top 20 upregulated genes and top 20 downregulated genes in the parenchyma in designated comparisons
| Air |
Ozone |
Males |
Females |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Females vs. Males |
Females vs. Males |
Ozone vs. Air |
Ozone vs. Air |
||||||||
| Gene | FC | Adjusted P Value | Gene | FC | Adjusted P Value | Gene | FC | Adjusted P Value | Gene | FC | Adjusted P Value |
|
Top 20 upregulated genes | |||||||||||
| Xist | 8.63 | 2.5E−138 | Xist | 67.38 | 0.00 | Ltf | 13.51 | 2E−59 | Retnla | 25.74 | 9E−209 |
| Mfap4 | 1.69 | 1.4E−17 | Kdm6a | 1.61 | 0.00 | Retnla | 13.03 | 4E−45 | Saa3 | 18.54 | 5E−86 |
| AI838599 | 1.58 | 1.4E−08 | Lrat | 1.51 | 0.00 | Orm1 | 9.06 | 5E−31 | S100a14 | 10.10 | 1E−74 |
| Gsg1l | 1.56 | 2.6E−05 | Wt1 | 1.46 | 0.00 | S100a14 | 7.94 | 2E−35 | Timp1 | 9.71 | 1E−128 |
| Kdm6a | 1.51 | 7.2E−09 | Gm14420 | 1.45 | 0.00 | Syt12 | 5.86 | 1E−28 | Ltf | 8.76 | 6E−35 |
| Cpa3 | 1.51 | 1.3E−04 | Eif2s3x | 1.42 | 0.00 | Timp1 | 5.72 | 8E−26 | Sprr1a | 8.34 | 1E−26 |
| Iqgap3 | 1.50 | 1.9E−04 | Pbdc1 | 1.42 | 0.00 | Phgr1 | 5.62 | 2E−19 | Chl1 | 7.98 | 6E−31 |
| Entpd8 | 1.50 | 3.5E−04 | RP23–32A8.1 | 1.41 | 0.00 | Chl1 | 5.15 | 3E−17 | Mcidas | 7.37 | 3E−34 |
| Eif2s3x | 1.49 | 6.2E−19 | 5530601H04Rik | 1.40 | 0.00 | Kng2 | 5.09 | 2E−17 | Phgr1 | 7.14 | 1E−34 |
| Cnr1 | 1.49 | 2.3E−04 | Gabra3 | 1.39 | 0.01 | Mfsd2a | 4.83 | 2E−31 | Gjb4 | 6.98 | 2E−22 |
| Rps29 | 1.48 | 5.3E−11 | Ifit1 | 1.37 | 0.00 | AU018091 | 4.81 | 2E−17 | Cldn4 | 6.95 | 1E−45 |
| Slc7a10 | 1.48 | 2.1E−08 | Ppp1r3a | 1.36 | 0.02 | Pbk | 4.55 | 1E−19 | Lrg1 | 5.94 | 9E−209 |
| Kdm5c | 1.47 | 1.4E−10 | Ddx3x | 1.34 | 0.00 | Atp10b | 4.48 | 3E−14 | Tgm1 | 5.86 | 8E−40 |
| Adamts17 | 1.47 | 2.7E−05 | Peg3 | 1.34 | 0.03 | AU040972 | 4.48 | 3E−29 | Mfsd2a | 5.62 | 7E−39 |
| Phex | 1.46 | 1.5E−05 | Ccl2 | 1.34 | 0.04 | Rasl10b | 4.46 | 1E−20 | Rasl10b | 5.60 | 2E−32 |
| Kcne4 | 1.45 | 3.0E−05 | Kdm5c | 1.34 | 0.00 | Rgs16 | 4.35 | 1E−16 | Fgg | 5.18 | 4E−19 |
| Gbp4 | 1.45 | 1.7E−04 | Entpd8 | 1.32 | 0.05 | Krtap17–1 | 4.35 | 1E−19 | Orm1 | 5.13 | 5E−17 |
| Ano5 | 1.43 | 2.4E−03 | Omd | 1.30 | 0.04 | Gjb3 | 4.31 | 2E−15 | Lcn2 | 5.06 | 7E−104 |
| Adam12 | 1.43 | 2.1E−03 | Pydc4 | 1.29 | 0.03 | Prss22 | 4.26 | 1E−11 | Slc26a4 | 4.96 | 1E−29 |
| Zmat4 | 1.42 | 2.8E−03 | Cftr | 1.28 | 0.05 | Dtl | 4.24 | 2E−22 | Pbp2 | 4.83 | 3E−15 |
|
Top 20 downregulated genes | |||||||||||
| Ddx3y | –56.61 | 0.0E+00 | Ddx3y | –46.14 | 0.00 | Ces1f | –4.57 | 2E−19 | Igfbp3 | –3.87 | 4E−32 |
| Eif2s3y | –39.79 | 0.0E+00 | Eif2s3y | –17.92 | 0.00 | Pon1 | –3.55 | 4E−14 | Ighv1–64 | –3.57 | 9E−11 |
| Kdm5d | –27.42 | 0.0E+00 | Kdm5d | –15.60 | 0.00 | Igfbp3 | –3.46 | 3E−17 | Ighv7–3 | –3.30 | 4E−09 |
| Uty | –15.35 | 2.9E−249 | Uty | –9.40 | 0.00 | Ifitm6 | –3.31 | 3E−17 | Gzmb | –3.05 | 2E−22 |
| Serpina3m | –2.24 | 4.7E−18 | RP24–540G19.3 | –2.12 | 0.00 | Tbata | –3.31 | 8E−09 | Colq | –2.99 | 1E−15 |
| RP24–540G19.3 | –2.21 | 1.7E−20 | Camk2b | –1.37 | 0.01 | Asgr1 | –3.26 | 2E−08 | Klre1 | –2.98 | 2E−13 |
| Mefv | –1.81 | 2.5E−09 | Arhgdig | –1.34 | 0.00 | Gm14964 | –3.21 | 1E−19 | Ncr1 | –2.95 | 3E−18 |
| Pla2g7 | –1.79 | 1.4E−09 | Col23a1 | –1.29 | 0.00 | Fmo3 | –3.17 | 5E−29 | Gm14085 | –2.92 | 7E−13 |
| F5 | –1.70 | 6.3E−09 | Myh14 | –1.29 | 0.04 | RP23–458B6.6 | –3.07 | 3E−09 | Prf1 | –2.89 | 5E−14 |
| Ms4a4a | –1.70 | 2.6E−07 | Pitpnc1 | –1.28 | 0.00 | Sult1d1 | –3.06 | 1E−09 | Gzma | –2.77 | 8E−23 |
| RP23–458B6.6 | –1.69 | 2.8E−07 | Hnrnpa0 | –1.26 | 0.01 | Mefv | –2.89 | 1E−12 | Pon1 | –2.74 | 1E−07 |
| Atp1a3 | –1.68 | 2.6E−07 | Ighv1–64 | –1.26 | 0.05 | Slfn4 | –2.89 | 1E−06 | S1pr5 | –2.67 | 1E−16 |
| Ccr2 | –1.67 | 6.3E−10 | Ehd4 | –1.24 | 0.04 | Gfy | –2.86 | 1E−06 | Npr3 | –2.66 | 2E−27 |
| Wfdc17 | –1.67 | 5.0E−07 | Tnrc18 | –1.24 | 0.04 | Ngp | –2.79 | 3E−06 | Nkg7 | –2.64 | 2E−17 |
| Itgam | –1.67 | 8.6E−08 | H2-Eb1 | –1.24 | 0.02 | Slfn1 | –2.72 | 7E−15 | Ccl5 | –2.64 | 2E−26 |
| Gad1-ps | –1.65 | 2.0E−06 | Crispld2 | –1.20 | 0.03 | Sell | –2.72 | 4E−21 | Eomes | –2.58 | 2E−09 |
| Ttn | –1.64 | 2.6E−07 | Zc3h7b | –1.18 | 0.04 | Irg1 | –2.71 | 5E−06 | Gm14964 | –2.57 | 2E−13 |
| Asprv1 | –1.64 | 1.0E−06 | Emr4 | –2.67 | 5E−13 | Klra9 | –2.53 | 9E−11 | |||
| Fgr | –1.62 | 1.8E−10 | Trpm2 | –2.63 | 2E−12 | Klrc2 | –2.53 | 2E−09 | |||
| Cd300lf | –1.60 | 2.0E−06 | Galnt15 | –2.62 | 1E−23 | Gprasp2 | –2.53 | 1E−10 | |||