Table 5.
Top 20 upregulated genes and top 20 downregulated genes in macrophages in designated comparisons
| Air |
Ozone |
Males |
Females |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Females vs. Males |
Females vs. Males |
Ozone vs. Air |
Ozone vs. Air |
||||||||
| Gene | FC | Adjusted P Value | Gene | FC | Adjusted P Value | Gene | FC | Adjusted P Value | Gene | FC | Adjusted P Value |
|
Top 20 upregulated genes | |||||||||||
| Xist | 1418.35 | 0.0E+00 | Xist | 207.53 | 0.00 | C4b | 36.59 | 1E−129 |
Lrg1 |
14.85 | 5E−45 |
| RP24–210C4.1 | 5.31 | 4.7E−10 | 2700099C18Rik | 1.96 | 0.02 | Lrg1 | 21.10 | 2E−94 |
Mafb |
14.82 | 8E−139 |
| 9430025C20Rik | 4.19 | 5.4E−11 | 1190002F15Rik | 1.93 | 0.02 | Mafb | 11.60 | 9E−40 |
Arg1 |
11.47 | 1E−29 |
| Gimap3 | 4.16 | 3.2E−08 | Erdr1 | 1.93 | 0.01 | Msr1 | 10.32 | 1E−130 |
C4b |
10.53 | 7E−25 |
| Gm26772 | 4.08 | 2.8E−07 | Pif1 | 1.92 | 0.02 | C1qb | 9.15 | 8E−24 |
Wfdc17 |
8.26 | 3E−49 |
| Tagln3 | 3.98 | 6.0E−08 | Troap | 1.90 | 0.02 | Clu | 8.33 | 1E−48 |
Ocstamp |
8.21 | 6E−24 |
| Thy1 | 3.86 | 3.6E−07 | Arhgef39 | 1.89 | 0.02 | Spp1 | 7.78 | 5E−93 |
Awat1 |
7.57 | 1E−25 |
| Gm3235 | 3.82 | 4.3E−06 | Cenpw | 1.87 | 0.02 | C1qa | 7.77 | 1E−20 |
C1qb |
7.56 | 1E−18 |
| Slc7a3 | 3.70 | 1.8E−08 | Ndc80 | 1.87 | 0.02 | Anpep | 7.73 | 2E−60 |
Tnfsf14 |
7.42 | 3E−47 |
| Muc6 | 3.70 | 7.5E−07 | Cdkn3 | 1.86 | 0.03 | Fads2 | 7.59 | 5E−28 |
Ear6 |
7.29 | 2E−21 |
| S100a6 | 3.67 | 6.5E−16 | Cd209b | 1.85 | 0.03 | Cldn4 | 7.44 | 3E−23 |
Msr1 |
6.92 | 2E−71 |
| Gm26668 | 3.55 | 1.8E−05 | Cdkn2d | 1.83 | 0.00 | Sash1 | 7.15 | 6E−38 |
Atf7ip2 |
6.77 | 8E−16 |
| Ltb | 3.51 | 1.4E−08 | Ckap2 | 1.82 | 0.02 | F13a1 | 7.15 | 1E−17 |
Mmp14 |
6.61 | 3E−30 |
| Gm26762 | 3.34 | 1.3E−05 | Cenph | 1.82 | 0.03 | Ablim1 | 7.05 | 1E−23 |
Socs3 |
6.13 | 2E−34 |
| Gm11973 | 3.32 | 3.1E−07 | Stmn1 | 1.82 | 0.03 | C1qc | 6.98 | 3E−18 |
Sash1 |
5.94 | 3E−29 |
| S100a4 | 3.24 | 2.0E−06 | Tacc3 | 1.81 | 0.03 | Syngr1 | 6.93 | 4E−27 |
Slc6a8 |
5.91 | 1E−29 |
| Gm12689 | 3.24 | 7.8E−12 | Knstrn | 1.81 | 0.03 | Wfdc17 | 6.04 | 3E−54 |
Anpep |
5.85 | 4E−45 |
| Gm8738 | 3.23 | 6.3E−07 | Cdk1 | 1.80 | 0.03 | Cfh | 5.98 | 5E−22 |
Spp1 |
5.76 | 1E−147 |
| Rps19-ps3 | 3.21 | 7.1E−12 | Cdca5 | 1.79 | 0.02 | Gimap4 | 5.82 | 1E−14 |
Fads2 |
5.74 | 8E−12 |
| Prkag2os1 | 3.19 | 9.0E−05 | Sapcd2 | 1.79 | 0.04 | Socs3 | 5.80 | 4E−59 |
Timp1 |
5.74 | 1E−30 |
|
Top 20 downregulated genes | |||||||||||
| Eif2s3y | –327.74 | 4.1E−189 | Ddx3y | –122.71 | 0.00 | Htra3 | –6.26 | 2E−59 |
Dnah11 |
–8.91 | 1E−52 |
| Ddx3y | –326.76 | 1.9E−182 | Eif2s3y | –114.76 | 0.00 | Dnah11 | –6.22 | 1E−26 |
Hmcn1 |
–8.06 | 2E−19 |
| Kdm5d | –162.74 | 2.7E−128 | Kdm5d | –40.98 | 0.00 | D630039A03Rik | –6.01 | 4E−35 |
Itgad |
–6.96 | 2E−41 |
| Uty | –111.81 | 2.8E−103 | Uty | –37.99 | 0.00 | Itgad | –5.66 | 2E−29 |
Adra2a |
–5.87 | 4E−19 |
| Pdpr | –7.21 | 1.4E−15 | Adap2 | –1.92 | 0.00 | Adra2a | –5.31 | 7E−16 |
Gm8113 |
–5.65 | 2E−80 |
| Gm14548 | –7.01 | 4.5E−31 | Kcnh4 | –1.92 | 0.00 | Gm8113 | –4.54 | 1E−45 |
Cd300lg |
–5.43 | 4E−40 |
| RP24–540G19.3 | –6.46 | 7.5E−11 | Gdap10 | –1.88 | 0.03 | Acaa1b | –4.54 | 2E−33 |
Htra3 |
–5.16 | 4E−49 |
| Krt80 | –5.67 | 1.3E−40 | Slfn10-ps | –1.85 | 0.03 | Sdk1 | –4.37 | 1E−14 |
Gabbr1 |
–5.07 | 9E−55 |
| Cog5 | –5.50 | 7.4E−20 | Gm15931 | –1.85 | 0.02 | Spag11b | –4.32 | 4E−26 |
D630039A03Rik |
–5.07 | 3E−38 |
| Hmgxb3 | –5.45 | 2.0E−24 | Hpse | –1.84 | 0.03 | Fabp1 | –4.28 | 5E−31 |
1810011O10Rik |
–4.72 | 2E−17 |
| Snx29 | –5.32 | 8.2E−18 | Hmgxb3 | –1.82 | 0.03 | Rbpms | –4.09 | 8E−29 |
Spag11b |
–4.50 | 5E−66 |
| Vcl | –5.16 | 1.1E−12 | Gm15635 | –1.82 | 0.04 | Gm12349 | –3.98 | 3E−21 |
Tgfb2 |
–4.45 | 2E−27 |
| Zfp526 | –5.15 | 5.5E−18 | Gm16185 | –1.80 | 0.03 | Kcnh4 | –3.94 | 1E−18 |
Hr |
–4.39 | 5E−54 |
| Rnf24 | –5.02 | 2.7E−17 | Sik2 | –1.80 | 0.03 | Slc1a3 | –3.67 | 1E−19 |
Klk8 |
–3.79 | 3E−33 |
| Mob3a | –4.92 | 1.3E−22 | Setd1b | –1.79 | 0.02 | Gabbr1 | –3.54 | 8E−15 |
Hepacam2 |
–3.78 | 1E−12 |
| Xylt1 | –4.90 | 4.3E−12 | Uprt | –1.79 | 0.03 | Mamdc2 | –3.49 | 6E−26 |
Fabp1 |
–3.76 | 1E−27 |
| Pira2 | –4.75 | 6.8E−50 | Hgf | –1.79 | 0.05 | Cd209b | –3.45 | 8E−09 |
Clcf1 |
–3.69 | 3E−45 |
| 4931406P16Rik | –4.59 | 1.4E−09 | Echdc1 | –1.78 | 0.03 | Atp2b4 | –3.43 | 3E−11 |
Cox6a2 |
–3.60 | 5E−07 |
| Mical3 | –4.58 | 2.1E−15 | Zfp955a | –1.77 | 0.03 | Tppp | –3.41 | 4E−11 |
Fam212a |
–3.58 | 5E−18 |
| Arhgef11 | –4.57 | 4.7E−24 | 9930111J21Rik1 | –1.77 | 0.05 | Gm13546 | –3.39 | 4E−17 | Trf | –3.47 | 2E−21 |