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Left ventricular perivascular fibrosis increases later in life in females independent of smooth muscle cell (SMC)-mineralocorticoid receptor (MR). Left ventricular (A) interstitial (scale bars = 50 µm) and (B) perivascular fibrosis (scale bar = 10 µm) were quantified in 3-, 12-, and 18-mo-old MR-intact and SMC-specific MR deletion (SMC-MR-KO) female mice; n = 5–9/group. Differences were assessed via two-way ANOVA. LV, left ventricular. Data are means ± SE; *P < 0.05.
