Figure 6.

Development of central and peripheral fatigue during the intermittent isometric exercise protocol (A, C, and E) and the ensuing pre- to postexercise change (B, D, and F) in neuromuscular function for controls (n = 8) and patients with heart failure with preserved ejection fraction (HFpEF; n = 8). Main effects were determined via 2-way mixed-model ANOVAs (group × time) for A, C, and E; independent group t tests were used to assess group differences in the pre- to postexercise change in neuromuscular function (B, D, and F). Data are presented as means ± SD. *Significant difference between groups, P < 0.05.