Figure 4.

Fig. 4. Associations between blood-based biomarkers (colored online): A: high-mobility group box 1 (HMGB1) and ASC levels in plasma extracted from the blood-draw executed before e-cigarette (e-cig) vaping challenge (“pre”). B: reactive oxygen species (ROS) production and ASC concentration quantified before e-cig vaping. C: nitrate-nitrite (NOx) and C-reactive protein (CRP) levels in serum quantified from the blood-draw executed after the e-cig vaping challenge and the second MRI protocol. Spearman’s correlation coefficients and the respective P values are reported in the box; 95% prediction and regression lines are indicated. Log transforms were used since the data were not normally distributed