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. 2021 Jan 30;13:23. doi: 10.1186/s13148-021-01017-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Genetic and epigenetic features of exon 3 do not control Oxtr expression. a Offspring receiving less parental care (MAN0) have decreased DNA methylation across exon 3 in the nucleus accumbens (13 male–female sibling pairs; MAN0: n = 7 males, 7 females; MAN1: n = 6 males, 6 females; mixed effect model with fixed effect of handling condition and random effects of individual and CpG site; Type II Wald F test F_(1,24) = 8.386, p = 0.018. CpG sites are numbered according to Additional file 1: Fig S1B. b DNA methylation in exon 3 is not robustly associated with Oxtr expression in prairie vole nucleus accumbens. Spearman’s rank correlation was used to determine correlation. CpG 36, the only site that has a significant correlation with Oxtr expression (not corrected for multiple comparisons) is shown in black. Sites that do not have a significant correlation with Oxtr expression are in gray. Spearman’s rho and p values for each site are in Additional file 1: Table S3