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. Author manuscript; available in PMC: 2021 Jan 30.
Published in final edited form as: Ann Intern Med. 2020 Jan 21;172(4):229–239. doi: 10.7326/M19-2936

Table 4.

Complications of HCT during the first 100 days and their attendant Day-200 Non-Relapse Mortality Hazard Ratios, 2013-2017.

Complications of allogeneic
hematopoietic cell transplant during
2013-2017
Number
of
patients*
Hazard Ratio for Day-200 Non-
Relapse Mortality (95% CI)
Peak total serum bilirubin ≥68.4 μmol/L (4 mg/dL) 123 11.94 (8.16 – 17.47)
Peak total serum bilirubin ≥171 μmol/L (10 mg/dL) 29 33.85 (20.06 – 57.11)
Serum creatinine 2-times baseline 254 6.63 (4.60 – 9.57)
Serum creatinine 3-times baseline 67 15.47 (9.97 – 24.01)
Renal Replacement Therapy 39 20.80 (13.03 – 33.22)
Mechanical ventilation 77 15.85 (10.72 – 23.44)
Jaundice + Renal Replacement Therapy + Mechanical ventilation 19 36.70 (19.31 – 69.77)
Any CMV infection 501 1.23 (0.73 – 2.08)
CMV DNA >250 IU/mL 288 2.33 (1.42 – 3.84)
CMV DNA >1000 IU/mL 138 2.82 (1.68 – 4.75)
CMV disease b 24 2.00 (0.72 – 5.56)
Gram negative bacteremia 74 5.16 (3.22 – 8.24)
Invasive mold infection 42 9.73 (5.83 – 16.22)
GVHD grade 2-4 784 1.45 (0.95 – 2.22)
GVHD grade 3-4 135 5.29 (3.59 – 7.81)
*

See Table 3, Frequency of events among all patients transplanted during 2013-2017.

Among CMV-seropositive patients only.